104 articles - From Friday Sep 29 2023 to Friday Oct 06 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Gastroenterol |
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| Clin Gastroenterol Hepatol |
PERCEPTIONS, DEFINITIONS, AND THERAPEUTIC INTERVENTIONS FOR OCCASIONAL CONSTIPATION: A ROME WORKING GROUP CONSENSUS DOCUMENT. Occasional constipation is a unique clinical entity characterized by infrequent but recurrent symptoms. Data is limited as consensus definitions have been lacking. Establishing a standardized definition and therapeutic recommendations provides a framework for future studies focusing on epidemiologic and symptoms-based outcomes. Further studies are needed to confirm and refine these recommendations. |
| Gut |
British Society of Gastroenterology guidelines for the diagnosis and management of cholangiocarcinoma. Quality of evidence is presented using the Appraisal of Guidelines for Research and Evaluation (AGREE II) format. The recommendations arising are to be used as guidance rather than as a strict protocol-based reference, as the management of patients with CCA is often complex and always requires individual patient-centred considerations. |
meta-analyses and systematic reviews
| Gut |
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Changing prevalence of chronic hepatitis B virus infection in China between 1973 and 2021: a systematic literature review and meta-analysis of 3740 studies and 231 million people. China has experienced remarkable decreases in HBV infection over the last four decades, but variations in HBsAg prevalence persist in subpopulations. Ongoing prevention of HBV transmission is needed to meet HBV elimination targets by 2030. |
| Hepatology |
Pre-emptive TIPS in high-risk acute variceal bleeding. An updated and revised individual patient data meta-analysis. The updated two-stage IPD-MA confirms the significant survival advantage of p-TIPS in high-risk patients with cirrhosis and AVB. As a result, we recommend p-TIPS as the preferred first-choice treatment for these patients. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
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Design of the phase 3 MAESTRO clinical program to evaluate resmetirom for the treatment of nonalcoholic steatohepatitis. The MAESTRO clinical programme was designed in conjunction with regulatory authorities to support approval of resmetirom for treatment of NASH. The surrogate endpoints, based on week 52 liver biopsy, serum biomarkers and imaging, are confirmed by long-term clinical liver-related outcomes in MAESTRO-NASH (month 54) and MAESTRO-NASH-OUTCOMES (time to event). |
In severe alcohol-related hepatitis, acute kidney injury is prevalent, associated with mortality independent of liver disease severity, and can be predicted using IL-8 and micro-RNAs. Incident AKI is associated with 90-day mortality independent of liver function. Prednisolone therapy was associated with reduced incident AKI. IL-8 and several miRNAs are potential biomarkers to predict AKI. Novel therapies to prevent incident AKI should be evaluated in AH to reduce mortality. |
Novel symptom clusters predict disease impact and healthcare utilisation in inflammatory bowel disease: Prospective longitudinal follow-up study. Novel model-based clusters identify patients with IBD at higher risk of adverse disease outcomes who are high-volume users of healthcare. |
Prospective comparison of diagnostic tests for bile acid diarrhoea. Diagnosis of bile acid diarrhoea using empirical treatment was inadequate. Exploration suggested considerable improvements in the sensitivity of C4-based testing, offering potential widely available diagnostics. Further validation is warranted. NCT03876717. |
| Am J Gastroenterol |
A Predictive Model to Identify the Effects of Transcutaneous Sacral Nerve Stimulation with Pelvic Floor Exercises in Faecal Incontinence after Surgery for Anorectal Malformation. tSNS with PFEs is effective for most FI patients after CARM surgery except when rectum deviates from the puborectal muscle centre, puborectal muscle rupture occurs, or EAS is absent with a low ASP. |
ADALIMUMAB VERSUS INFLIXIMAB IN LUMINAL PEDIATRIC CROHN'S DISEASE: COMPARABLE OUTCOMES IN A PROSPECTIVE MULTICENTER COHORT STUDY. Children with Crohn's disease achieved favourable outcomes at one year with either ADA or IFX as first antiTNF agents. Those receiving IFX did not have significantly superior outcomes compared to clinically similar children receiving ADA. |
Clinical features and treatment response to topical steroids in ethnic and racial minority patients with eosinophilic esophagitis. Few EoE patients at our center were Hispanic, and they had similar clinical presentations as non-Hispanics. The non-White EoE group was larger, and presentation was less dysphagia-specific. Non-White patients were also less than half as likely to respond to tCS. |
Clinical outcomes after endoscopic management of low-risk and high-risk T1a esophageal adenocarcinoma: A multicenter study. High-risk T1a EAC patients undergoing successful EET had a substantially higher rate of extra-esophageal metastases compared to low-risk T1a EAC on long term follow-up. These data should be factored into discussions with patients while selecting treatment approaches. Additional prospective data in this area are critical. |
Colorectal cancer screening receipt does not differ by 10-year mortality risk among older adults. Past-year CRC screening does not differ by predicted 10-year mortality risk. An age-based approach to CRC screening results in under-screening of older, healthier adults and over-screening of younger adults with chronic conditions. Personalized screening with incorporation of individual life expectancy may increase the value of CRC screening programs. |
Gastric Alimetry® expands patient phenotyping in gastroduodenal disorders compared to gastric emptying scintigraphy. GA improves patient phenotyping in chronic gastroduodenal disorders in the presence and absence of motility abnormalities with increased correlation with symptoms and psychometrics compared to gastric emptying status and Rome IV criteria. These findings have implications for the diagnostic profiling and personalized management of gastroduodenal disorders. |
Maternal and Neonatal Outcomes in Vedolizumab and Ustekinumab Exposed Pregnancies: Results from the PIANO registry. This analysis of UST and VDZ exposure during pregnancy suggests no increase in complications compared to TNFs, immunomodulators and combination TNFs/immunomodulators. No signal was found for increased placental events with either therapy. Continuation of UST and VDZ throughout pregnancy is recommended. |
OPTIMIZING TIMING OF FOLLOW-UP COLONOSCOPY: A PILOT CLUSTER RANDOMIZED TRIAL OF A KNOWLEDGE TRANSLATION TOOL. An application that provides colonoscopy surveillance intervals may help endoscopists with guideline congruence, especially those with a lower pre-intervention congruence with guideline recommendations. (ClincialTrials.gov number, NCT04889352). |
SIGNIFICANT REDUCTION IN THE DIAGNOSIS OF BARRETT'S ESOPHAGUS AND RELATED DYSPLASIA DURING THE COVID-19 PANDEMIC. There was a significant decline in the number of BE and BE-related dysplasia diagnoses during the COVID-19 pandemic, with an almost 50% reduction in the amount of dysplasia diagnosed in the early pandemic. The absence of a compensatory increase in diagnoses in the pandemic-Phase II and III periods may result in deleterious downstream effects on esophageal adenocarcinoma morbidity and mortality. |
Satisfaction with life in IBS is associated with psychological burden rather than gastrointestinal symptom severity. Higher physical and mental quality of life, but not gastrointestinal symptom severity, were independently associated with higher general life satisfaction in IBS. These findings reinforce the clinical need in IBS treatment to focus on the full extent of the disorder and not merely on gastrointestinal symptom improvement. ClinicalTrials.gov Identifier NCT00775060. |
The Association between Homelessness and Key Liver-Related Outcomes in Veterans with Cirrhosis. Homelessness in veterans with cirrhosis is associated with increased all-cause mortality, however this is likely mediated primarily through non-liver-related factors. Future studies are needed to explore drivers of mortality and improve mitigation strategies in these patients. |
The Impact of Patient's Primary Language on Inpatient Gastrointestinal Bleeding Outcomes. Disparities exist in GIB outcomes among patients with PLOE but these gaps narrow at hospitals with higher percentages of PLOE patients. Cultural and linguistic competence may improve outcomes in this vulnerable group. |
Transcutaneous auricular vagal nerve stimulation is effective for the treatment of functional dyspepsia: a multicenter, randomized controlled study. Our study firstly showed that 4-week taVNS (both 10Hz and 25Hz) was effective and safe for the treatment of adult FD. (clinicaltrials.gov number NCT04668534). |
| Endoscopy |
Forced cold snare polypectomy is related to cold snare defect protrusions and incomplete polyp resections: A prospective observational study. FCSP was performed on 105 polyps (8%) in this study. There is the possibility that FCSP is associated with the occurrence of CSDPs and IPR. Further studies are necessary in the future to confirm our results. |
Interval post-colonoscopy colorectal cancer following a negative colonoscopy in a fecal immunochemical test-based screening program. Risk of iPCCRC within a FIT-based CRC screening program was low during the first years after colonos-copy but, after 2.5 years, was the same as the risk in FIT-negative individuals at 2 years, when they are reinvited for screening. Colonoscopy quality may therefore require further improvement and FIT screening interval may need to be reduced after negative colonoscopy. |
| Gastroenterology |
HBV DNA AND HBSAG LEVELS AT 24 WEEKS OFF-TREATMENT PREDICT CLINICAL RELAPSE AND HBSAG LOSS IN HBEAG NEGATIVE PATIENTS WHO DISCONTINUED ANTIVIRAL THERAPY. Among HBeAg negative CHB patients who discontinued antiviral therapy and who did not experience clinical relapse before FU W24, serum levels of HBV DNA and HBsAg at FU W24 can be used to predict subsequent clinical relapse and HBsAg clearance. A combination of HBsAg <100 IU/mL with HBV DNA <100 IU/mL identifies patients with a low risk of relapse and excellent chances of HBsAg loss, and could potentially be used as an early surrogate endpoint for studies aiming at finite therapy in HBV. |
| Gastrointest Endosc |
Prospective study of diagnostic yields of flexible spectral imaging color enhancement installed in colon capsule endoscopy for colorectal polyps and tumors. CCE-FICE improved the detection rates for al CRTs except adenocarcinomas, =10 mm and protruding polyps, when compared to CCE-WL (UMIN 000021125). |
Sex Differences Impact Ergonomic Endoscopic Training for Gastroenterology Fellows. Physical differences exist between male and female trainees, and current endoscopic equipment may not be optimized for smaller hand sizes. This study highlights the urgent need for formal ergonomic training for trainees and trainers with consideration of stature and hand size to enhance safety, comfort, and equity in the training and practice of endoscopy. |
| Gut |
HLA-DPA1*02:01~B1*01:01 is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells. Results NKp44+NK cells were enriched in livers, and intrahepatic bile ducts of individuals with PSC showed higher expression of HLA-DP. HLA-DP haplotype analysis revealed a highly elevated PSC risk for and provide clinical and functional data implicating NKp44+NK cells that recognise HLA-DPA1*02:01-DPB1*01:01 expressed on cholangiocytes in PSC pathogenesis. |
Lactobacillus gallinarum-derived metabolites boost anti-PD1 efficacy in colorectal cancer by inhibiting regulatory T cells through modulating IDO1/Kyn/AHR axis. Objective Gut microbiota is a key player in dictating immunotherapy response. We aimed to explore the immunomodulatory effect of probiotic is a potential adjuvant to augment anti-PD1 efficacy against CRC. |
Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. The RPLS signature could be a novel metric of chemotherapy outcome in iCCA. Further development and validation of this transcriptomic signature is warranted to develop precision chemotherapy strategies in these settings. |
Novel function of MOTS-c in mitochondrial remodelling contributes to its antiviral role during HBV infection. MOTS-c has the potential to serve as a biomarker for the progression of HBV infection while also enhancing antiviral efficacy. These findings present a promising innovative approach for effectively treating patients with CHB. Furthermore, our research uncovers a novel role for MOTS-c in regulating MYH9-actin-mediated mitochondrial dynamics and contributing to mitochondrial biogenesis. |
Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial. In this proof-of-concept study, a prebiotic intervention attenuated reward-related brain activation during food decision-making, paralleled by shifts in gut microbiota. |
| Hepatology |
Genomic approaches to explore susceptibility and pathogenesis of alcohol use disorder and alcohol-associated liver disease. In this review, we described multiple genomic approaches and their implications to investigate the susceptibility and pathogenesis of both AUD and ALD. We concluded our review with a discussion of the knowledge gaps and future research on genomic studies in these two diseases. |
Risk of liver-related events in metabolic dysfunction-associated steatohepatitis (MASH) patients with fibrosis: A comparative analysis of various risk stratification criteria. The risk of LRE is similar in patients with high-risk MASH and with F2-F4 fibrosis without MASH. The use of LSM=10 KPa or AGILE 3+ >0.67 could be an accurate option to identify MASLD patients worthy to be included in clinical trials. |
The clinical and financial burden of nonhepatocellular carcinoma focal lesions detected during surveillance of patients with cirrhosis. Non-HCC HFL are frequently detected in patients with cirrhosis, do not impact prognosis but trigger substantial costs. This burden must be considered in cost-effectiveness analyses of future personalized surveillance strategies. |
| J Neurogastroenterol Motil |
Characteristics and risk factors of Functional Dyspepsia fulfilling the Rome IV Criteria overlapping with Gastroesophageal Reflux Disease, Irritable Bowel Syndrome, and Functional Constipation in South China. FD overlap was quite common in China with high economic burden and poor quality of life, FD patients with history of gastroenteritis, anxiety, depression, and poor sleep quality were more likely to have overlap disorders. Awareness of the physical and psychosocial stressors in overlapping condition would help optimize the management of FD overlap in clinical practice. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
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Review article: The complex interplay between diet and Escherichia coli in inflammatory bowel disease. Preclinical and some clinical trial data suggest that E. coli and other Proteobacteria interact with certain dietary components to promote gut inflammation. Well-designed clinical trials are required before dietary recommendations for disease management can be made. |
| Clin Gastroenterol Hepatol |
Longitudinal Outcomes Associated with Metabolic Dysfunction-Associated Steatotic Liver Disease. A Meta Analysis of 129 Studies. The present study emphasizes the association between MASLD and its clinical outcomes including cardiovascular, metabolic, oncological, and other outcomes. The multisystemic nature of MASLD found in this analysis requires treatment targets to reduce systemic events and end organ complications. |
| Gastroenterology |
| J Hepatol |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Hepatology |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Gastroenterology |
| Gut |
| J Hepatol |